Circadian variations of infarct size in acute myocardial infarction

Circadian variations of infarct size in acute myocardial infarction.

BACKGROUND The circadian clock influences a number of cardiovascular (patho)physiological processes including the incidence of acute myocardial infarction. A circadian variation in infarct size has recently been shown in rodents, but there is no clinical evidence of this finding. OBJECTIVE To determine the impact of time-of-day onset of ST segment elevation myocardial infarction (STEMI) on in...

Circadian variations of infarct size in STEM1.

Circadian Dependence of Infarct Size and Acute Heart Failure in ST Elevation Myocardial Infarction

OBJECTIVES There are conflicting data on the relationship between the time of symptom onset during the 24-hour cycle (circadian dependence) and infarct size in ST-elevation myocardial infarction (STEMI). Moreover, the impact of this circadian pattern of infarct size on clinical outcomes is unknown. We sought to study the circadian dependence of infarct size and its impact on clinical outcomes i...

Infarct Size in Awake Dogs With Acute Myocardial Infarction

Background. Short-term cholesterol feeding has been shown to affect vasomotor tone and increase infarct size in anesthetized rabbits. The purpose of the study was to determine whether acute hypercholesterolemia reduced collateral flow to ischemic myocardium and increased infarct size in the awake dog. Methods and Results. Acute myocardial infarction was produced in awake dogs by a 4-hour left a...

Estimation of Acute Myocardial Infarct Size

This study was performed to determine the relationship between myocardial infarct size estimated by serum CK-MB methods and the extent of irreversible injury in acute myocardial infarction. In 321 consecutive patients, infarct size was estimated by different mathematical models, and in 22 patients who died in hospital, the extent of myocardial necrosis was determined by autopsy. We also investi...